Tire vibration while driving is a clear sign that something is wrong with your wheels or suspension system. Here are the top causes: 1. Wheel Imbalance The most common cause, especially Can Over Inflated Tires Cause Vibration 'What the [Expletive] Is That?:' Customer Complains Car is 'Shaking Like Crazy.' Then His Mechanic Takes a Closer Look At The Tire Steering Wheel Vibration: My Car Shakes While I'm Driving Why Are My Tires Vibrating? TIRECRAFT Wheel Balancing Breakdown TIRECRAFT Causes of Tire Vibration