What Is the Difference Between Freebase E Juice and Nicotine Salts? iSmokeKing.se Freebase Nicotine & Nicotine Salts Difference Between Nic Salt and E Liquid Vape Big YES, you CAN mix salt and freebase nicotine! But, like oil and water they may separate in your tank pod bottle so we recommend shaking mixing before use! That includes after sitting overnight. , ., E Liquid vs Nic Salt: What's the Difference and Which Should You Buy? Freebase vs Nicotine Salts: The Difference Explained